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Re: Lexapro side-effects » pharmrep

Posted by Simcha on September 1, 2002, at 5:35:06

In reply to Re: Lexapro side-effects » dr dave, posted by pharmrep on August 31, 2002, at 22:13:49

I'll chime in here even though I wasn't asked.

Because many of us who take an SSRI for OCD AND MDD need the higher dose.

Sure, Celexa at 20mg had very few side effects. Of course it did not work as well for me as the 40mg dose. At that level Celexa made my teeth grinding worse. The pdoc explained that this was because the SSRIs (all of them) block dopamine receptors in the joints. He gave me clonazepam to help with this. It did the trick.

I have no confidence that Lexapro will be any different in this regard for people like me. More than likely, following the Lexapro dosing guide, I would need 20mg of Lexapro. OK, so it's only the s-isomer. (And do we really know that the r-isomer is inert since we really don't understand just how these drugs really work in the brain?) Even with only the allegedly uniquely active s-isomer we are still dealing with an SSRI. All SSRIs have side effects that include some form of sexual side-effects, sweating, and for me teeth grinding. The sexual side effects are handled nicely by the addition of WellbutrinSR to my mix and over time that side effect has subsided.

Oh, yes, I plan on sticking with Citalopram as long as insurance companies stick by it. Of course, Forest has made Lexapro slightly cheaper therefore it is more attractive to insurance companies. Oh, and Forest has five years left on the patent for Citalopram? Goody, they can make Lexapro look attractive to insurance companies to insure Lexapro's success so that it makes a handsome profit. Forest can rest assured that so long as they hold the patent for citalopram they will continue to make a handsome profit even if people who need it will, most likely, have to jump through extra hoops to get their insurance companies to pay for it.

This is just a business to these huge drug companies. I don't buy the bit that Forest is being benevolent "passing up profits" by making Lexapro cheaper. It's a great strategy business wise. It's not going to convince me that they are the "Mother Theresa" of drug companies.

Simcha


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