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Re: Unresponsive to SSRIs? What worked? » oracle

Posted by oracle on September 19, 2002, at 15:59:19

In reply to Re: Unresponsive to SSRIs? What worked? » oracle, posted by Silly Brain on September 19, 2002, at 13:05:53

> I'm not sure I understand. Dopamine is affected by stimulants/amphetamines, such as ritalin, dexedrine, adderall...and before they were given to hyper kids for focus they were given to depressed housewives for lack of motivation.

motivation=NE

In fact, an ad from the 60s refers to Dexedrine Spansule as the model antidepressent. That's far from the AP effects on dopamine, but still dopamine stimulating all the same. My understanding is that Wellbutrin has somewhat less stimulating effects on dopamine than amphetamines.

All amphetimines highly effect NE.
If dopamine was highly effected
ones would expect AP like effects.
Also it does seem that pleaying with dopamine
can has neast effects.

> How do you know you are getting an NE effect as opposed to a 5HT effect?

Prozac at high dose, nothing
Zoloft, nothing
Any SSRI, nothing
TCA's that have a lessor effect on NE are less effective for me.


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