Posted by phil_b on October 1, 2002, at 15:37:07
In reply to Hopeful about duloxetine, posted by Mr. Scott on February 3, 2002, at 12:47:28
I just read an article in Medscape about duloxetine (Cymbalta). Apparently it has a "cleaner" side-effect profile meaning that the side effects (as you probably know, there are ALWAYS side-effects), are less and less bothersome. Here are some potential benefits of duloxetine over Effexor:
>duloxetine at 80 mg/day (starting dose is 60) does not induce hypertension
>duloxetine does not produce any clinically significant effects on body weight
>duloxetine was shown to be safe and well-tolerated in a dose range of 40-120 mg/day (administered BID) or at 60 mg daily
>BUT, no differences between treatment groups were detected in female sexual function when it was compared to Paxil; and males experienced greater orgasm delay just like Paxil.
Well, 4 out of 5 is not bad. I am in chronic pain and take Pamelor (nortryptiline), the old fashioned TCA, but it does really help. I really dislike the side effects of Pamelor and am hoping that duloxetine will work better for me. I am also hoping that it can be used in conjuction with Pamelor - using lower doses of each and achieving a better side effect profile.
I contacted Eli Lilly to volunteer for a study using duloxetine but could not because of other meds I am taking (pain meds). I spoke to a study coordinator who told me she was very impressed with the study's findings. It should be available by prescription late this year or early 2003. Apparently, duloxetine is being studied for "stress urinary incontinence" also.
poster:phil_b
thread:91928
URL: http://www.dr-bob.org/babble/20020930/msgs/121847.html