Posted by pharmrep on October 11, 2002, at 2:23:53
In reply to lexapro (P.I.) dose dependant adverse events, posted by pharmrep on September 1, 2002, at 0:00:38
*** I dont know what studies dr dave is looking at other than they are from europe...the studies in the usa have different parameters (like separating the mg's and not adding/averaging the #'s) here are the #'s from the US package insert. it is also not realistic to compare the celexa pi to the lexapro pi since they are both different groups (even though lexapro has better #'s, its not a valid comparison) I do stick by my statement (and the FDA'S) that at 10mg lexapro has side effects and discontuation due to adverse events comparable to placebo.
> Some of the more common adverse events (as listed in the package insert) are as follows:
>
> adverse event......Placebo.(311 patients)/...10mg Lexapro.(310 patients)/...20mg Lexapro (125 patients)
> insomnia..............4%.................................7%..........................................14%
> diarrhea..............5%.................................6%..........................................14%
> dry mouth...........3%.................................4%...........................................9%
> somnolence.........1%.................................4%...........................................9%
> dizziness..............2%.................................4%...........................................7%
> sweating increased1%.................................3%...........................................8%
> constipation.........1%.................................3%...........................................6%
> fatigue.................2%.................................2%...........................................6%
> indigestion...........1%.................................2%...........................................6%
>
> The overall incidence rates of adverse events in 10mg Lexapro treated patients (66%) is similar to that of the placebo treated patients (61%), while the incidence rate in 20mg Lexapro treated patients was greater (86%).
poster:pharmrep
thread:109458
URL: http://www.dr-bob.org/babble/20021006/msgs/123190.html