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Re: Buspar/buspirone

Posted by jflange on November 7, 2002, at 16:01:01

In reply to Re: Buspar/buspirone » Franz, posted by Ritch on November 3, 2002, at 16:10:00

I agree with Ritch that Buspar does not work well as a monotherapy but ever since I used it in combination with Zoloft, it has been a >much< more effective treatment for anxiety than ssris alone or ssris with a benzo.
While the exact mechanism of Buspar is unknown, the theory is that it both agitates and inhibits the reuptake of serotonin. Taken with an ssri, Buspar can really boost the good effects of an ssri without all the unpleasant side effects of simply increasing the ssri dose. I think, too, it must modulate these S1 receptors in some way that adresses anxiety where ssris do not.
Franz, I think you do not hear much about this drug because it is a sort of disappointing precursor to the ssris, and has never had the marketable quality of being a magic bullet. But hey, it does have one thing over clonazepam: no withdrawals!
jflange


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