Posted by Geezer on November 14, 2002, at 11:04:15
In reply to Re: To Geezer, posted by Denise528 on November 14, 2002, at 8:44:04
> Hi Geezer,
>
> I thought that Wellbutrin, stimulants, remeron and nardil all affected dopamine in some way.
>
>
> DeniseHi Denise,
Although Wellbutrin is supposed to have an impact on dopamine it is so minimal as to be almost nonexistent. The primary effect from Wellbutrin pertains to norep. You are correct, stimulants (Dexidrine, etc.) do have a direct influence on dopamine, they tend to release or "flood" the brain with dopamine, but pstims can not be regarded as ADs in the same sense that TCAs or SSRIs would be (due to there abuse "potential" they are classified as class II controlled substances). I have a history of Dexidrine abuse dating back to the 60's and 70's - I have been clean for many years. I have no argument with the regulation, what I do object to is the complete lack of research on dopaminergic ADs simply because the governing regulatory agencies would never approve such a drug.
I believe Remeron has an effect on serotonin and at higher does norep. I took it for 2 months at 45mg. with no effect. Same result with Wellbutrin at 450mg for the same time period.
Nardil I know very little about (took it back in the 70s), would have to research that a bit. Parnate, another MAOI, was said to have secondary metabolites of amphetamine (like Dexidrine), but I now hear conflicting reports on that. It is one of the best drugs for oldtimers like myself who no longer respond to the new ADs.
Please don't take these comments as any kind of a predictor of your results with these medications. I am 58, have been in treatment for more than 30 years, and my illness is progressive. I am part of the 30% group unresponsive to the modern drugs.
I can only hope for future improvements and that progress is hindered by regulatory obstruction.Wish you the very best in your treatment,
Geezer
poster:Geezer
thread:127463
URL: http://www.dr-bob.org/babble/20021108/msgs/127616.html