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Extrapyramidal symptoms and dopamine » Dinah

Posted by IsoM on December 11, 2002, at 14:53:09

In reply to Re: Ok, now I'm (still) confused » medlib, posted by Dinah on December 11, 2002, at 12:03:51

Dinah, most EPS are seem with any medication that depletes or lowers dopamine levels. Anti-psychotics are notorious for causing these problems. Parkinson's symptoms are similar to EPS because of the way the disease affects dopamine levels. Dopamine is also involved with pleasure, contentment, & a general overall good alert feeling. Stimulants increase dopamine levels. It is very complicated the way neurotransmitters interact (as you already know).

So medlib was saying that many SSRIs seem to lower dopamine levels over time. Lower dopamine levels lead to blunting of emotions like motivation & enthusiasm & can also lead to some EPS problems such as rigidity (like jaw clenching).

This site gives you an idea of what some EP symptoms are:
http://www.hubin.org/publicfamilyinfo/treatment/side_effects/side_effects_6_en.html


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poster:IsoM thread:131276
URL: http://www.dr-bob.org/babble/20021210/msgs/131354.html