Posted by Ritch on December 16, 2002, at 9:38:59
In reply to TCA discontinuation???, posted by johnj on December 15, 2002, at 21:33:18
> Hello,
> I was hoping anyone that was on a TCA could let me know how they titrated off. I went from 50 mg nortryptline to 40 and don't feel so good. I was suprised that such a small amount could affect me. Last week, by accident, took 70 instead of my normal 50. I thought I took a 25 mg plus 2-10mgs, but I took my normal 50 plus the 2 tens. The second day I felt horrible and figured out what I had done. My doc wants me to get down to 30 mgs and then start lexapro. Since I have a lot of anxiety I don't know if the ssri is a good idea. It was sure nice the second day I was on 40 to feel more in touch with the world and I was not irritable at all, but my sleep sucks and I have muscle spams due to the lack of sleep. Man, I hate these drugs...a necessary evil is so true. Thanks all
> johnj
> You out there Colin Wallace or Ron Hill?John, I always seemed to get a mild hypomania as a "rebound" effect from discontinuing the sedative TCA's (and Remeron). When I was taking 150mg of doxepin I dropped it in half to 75mg with no problems, and then dropped that to 25mg with no problems (got some insomnia when I stopped it entirely, however). I found nortriptyline to work quite well with an SSRI in the past (Celexa and then Zoloft). Lexapro shouldn't interact with the nortriptyline since it doesn't significantly inhibit p450IId6 liver enzymes (it shouldn't effect the level of nortripytline in your blood by adding it). When I was taking Zoloft with it (nortriptyline), the Zoloft boosted the levels of NT significantly (Z. does inhibit metabolism/clearance of NT), and I got a little jumpy as a result. hope this helps
poster:Ritch
thread:131944
URL: http://www.dr-bob.org/babble/20021210/msgs/131989.html