Posted by Ritch on January 24, 2003, at 13:33:32
In reply to Re: Ritch, posted by cybercafe on January 24, 2003, at 12:59:57
> >
> > Hi, I know what you mean. Barf=can't take this medicine, sorry! Thanks for listing your meds/dosages. I found Zoloft great for depression/panic, etc., BUT it created so much nausea and diarrhea that I could't hack it. The first and simplest thing that might be done is to switch SSRI's (since Z. works so well for your anx.). As far as personal experience with SSRI-induced nausea goes I got the least from Prozac and Celexa. I did get nausea for a few days with Prozac and Celexa, but it did fade rapidly, Zoloft nausea did not fade at all. I would ask your pdoc about a flip from Zoloft to either Prozac, Celexa, or Lexapro and see what happens.... OH, just a postscript here, but the the Zoloft induced nausea may just SEEM like Remeron withdrawal...
>
> hmmm.. is that because zoloft hits dopamine the strongest and dopamine chemoreceptors cause nausea/emesis/vomiting...?
> i think thats why anti-dopamine/anti-psychotic drugs are used to relieve nausea (from cancer treatment mostly, i think)
>
> i would like to think that instead of some hellish lifetime of trial and error, there can be a smart way to predict which drugs are more or less likely to give you certain effects
>
> heh... i think all patients with treatment resistant mental illness should be given access to courses in psychopharmacology, functional neuroanatomy, and genetics, at the very leastHi Cyber, I think the Zoloft nausea thing is primarily the intense serotonergic activity, because I also got the worst diarrhea from it than any of the other SSRI's. I've taken dexedrine and Ritalin (at much higher relative doses than Zoloft-and little GI upset at all on stims) and I never got nauseated like THAT. The DA reuptake inhibition of Zoloft is mild (but it is the most active of the SSRI's in that regard), and it probably does contribute a little to the nausea it provokes.
poster:Ritch
thread:136965
URL: http://www.dr-bob.org/babble/20030119/msgs/137347.html