Posted by Ron Hill on January 26, 2003, at 0:14:39
In reply to Re: fighting anhedonia by increasing reward pathway » hok, posted by Larry Hoover on January 24, 2003, at 14:22:03
> If you find nicotine useful, you needn't smoke to obtain it. You could use nicotine patches or nicotine gum. At least you'd be avoiding the adverse lung effects.
>
> Lar
------------------Larry,
I think it's more than just the nicotine. It's also (maybe primarily?) the MOI-A and MOI-B effects.
-- Ron
P.S. By the way, I enjoy your posts. They are typically quite informative.
: Life Sci 2001 Feb 2;68(11):1231-41 Related Articles, Links
2-Naphthylamine, a compound found in cigarette smoke, decreases both monoamine oxidase A and B catalytic activity.Hauptmann N, Shih JC.
Department of Molecular Pharmacology and Toxicology, School of Pharmacy, University of Southern California, Los Angeles, USA. hauptman@neotherapeutics.com
Cigarette smokers exhibit a lower monoamine oxidase (MAO; EC 1.4.3.4) activity than nonsmokers. MAO is located in the outer membrane of mitochondria and exists as two isoenzymes, MAO A and B. MAO A prefers 5-hydroxytryptamine (serotonin), and MAO B prefers phenylethylamine (PEA) as substrate. Dopamine is a substrate for both forms. 2-Naphthylamine is a carcinogen found in high concentrations in cigarette smoke. The results of this study show that 2-naphthylamine has the ability to inhibit mouse brain MAO A and B in vitro by mixed type inhibition (competitive and non-competitive). The Ki for MAO A was determined to be 52.0 microM and for MAO B 40.2 microM. The inhibitory effect of 2-naphthylamine on both MAO A and B catalytic activity, supports the hypothesis that smoking decreases MAO activity in vivo, instead that smokers with lower MAO activity are more prone to become a smoker.
PMID: 11233991 [PubMed - indexed for MEDLINE]
poster:Ron Hill
thread:137341
URL: http://www.dr-bob.org/babble/20030125/msgs/137570.html