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Re: Prozac/BuSpar combo: good or bad?

Posted by jflange on March 11, 2003, at 22:55:07

In reply to Prozac/BuSpar combo: good or bad?, posted by yeltom on March 11, 2003, at 20:33:15

yeltom:

Here's an article about Prozac and Buspar. There's a lot of jargon, but it's nicely detailed.
http://www.biopsychiatry.com/busmech.htm

In a nutshell: Buspar is both a serotonin agonist and antagonist, and it boosts levels of dopamine and noradrenaline. Because of its agonist/antagonist status with respect to serotonin, it both works in tandem with and against the effects of Prozac in terms of increasing serotonin.

Most importantly, Buspar works well as an augmenting agent with SSRIs of all stripes, including Prozac. It targets anxiety, but since it complements some SSRI therapy, it can also be useful in depression as well.

Hope that helps,
jflange


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