Posted by ace on March 12, 2003, at 20:14:36
OK my fellow med-heads,
This is my position. Around 15 weeks on Nardil OCD has only decreased by 40-60%. I am very strict with AD's and I class this as a partial response. Of course, you know from my earlier posts Nardil has been a life saver in so many aspects I LOVE IT!
But we must have OCD treated. After searching EXTENSIVELY through the literature I thought clonazepam was our best bet. Told Dr. today but he said, here in Australia, it is only prescribed for Epilepsy and there is a big black market for it.
Next bet was Lithium. I still have quite a few up my sleeve, but we will try Lithium first as the literature revealed almost as many positive OCD responses (as augmenter) as clonazepam (predominately as augmenter).
Now I must say that I have read conflicting statements on Lithium just as I have on Olanzapine. Apperently it unequivoally will strongly potentiaite Nardils MAOI serotonin agonism. This is what I want. But once again, and to a lesser extent, I heard it was serotonin antagonist. Now I must confess I have quite a bit of study to do on Monoamine receptor subtypes (This comes in another 6 weeks at uni).
But can anyoneone help with this?
Also, less technicals questions...
1. S/effects?
2. withdrawal
3. Most important, EFFICACYIt is stated to be a VERY good augmenter for OCD, but apart from serotonin what other ligands are we dealing with??
The pathophysiology of my derealization and phobic anxiety is not by any means totally serotonin based -- I'm reasonably sure of this. I think it has more to do with Noradrenaline, Dopamine, and GABA.
But Serotonin definately plays a part. When I took Periactan, the serotonin antagonist, I had a MAJOR relapse (only for 3 hours) in derealization, phobic anxiety, and OCD. So, in a way serotonin must be involved with all the probs (well it's involved in everything really) but ESP OCD.SO PLEASE LITHIUM USERS< ESP THOSE WHO TOOK IT WITH AN MAOI< TELL ME WHAT TO EXPECT?!!
Ace,
THE NARDIL CHAMPION OF AUSTRALIA,(WHO IS ABOUT TO EMBARK ON A NEW MISSION!, 105MG.
BTW, WHEN LITHIUM THERAPY STARTS, EITHER TOMMORROW OR SATURDAY) NARDIL WILL DROP BACK TO 90MG.
poster:ace
thread:208553
URL: http://www.dr-bob.org/babble/20030310/msgs/208553.html