Posted by djmmm on March 26, 2003, at 9:40:52
In reply to ATTN - Djjjm - Zyprexa /OCD question., posted by ace on March 25, 2003, at 18:48:37
> Hi Djmmm,
>
> Thankyou for your earlier responses. At the moment my Lithium augmented with Nardil has not relieved OCD (only 7 days on Lithium 2 days-250mg, 5 days 500mg)
>
> If the Lithium doesn't work I am really thinking that their could be a significant problem with dopaminergic transmission underlying my OCD. And this brings me to Zyprexa and Risperidone. As Dopamine antagonist (& they are serotonin agonists I've heard -at least for Zyprexa) I've heard that in augmentation with serotoninergic drugs they have produced a lot og great effects - some extrodinary.There is some evidence that OCD is highly genetically based, and that both serotonin and dopamine play important roles. Specificallly the D1, D2 and D4 receptors.
>
> Do you think Nardil + Lithium + Zyprexa (OR Risperidone) would be a good bet (or drop the Lithium?)Zyprexa is worth a try...you may want to consider something like Tegretol (which I have combined with Nardil in the past). Tegretol has anti-OCD properties...You may also want to consider cognitive behavioral therapy, CBT could be just the right therapy to get you OCD free.
> Do you believe, as I have reasoned, there very well could be a dopamine problem behind my OCD?
Yes, there is a lot of evidence for a strong dopamine component to OCD
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10920469&dopt=Abstract
>
> Any other comments most appreciated.
>
> BTW, clomipramine enhances noradrenaline, but we have that 'covered' with Nardil, right?
>
> Thanks, Djmmm.
>
> Ace,
poster:djmmm
thread:212688
URL: http://www.dr-bob.org/babble/20030325/msgs/213018.html