Posted by paulk on April 16, 2003, at 12:28:27
In reply to Re: Atomoxetine (Straterra) dsage, posted by Lexxey on April 16, 2003, at 12:06:30
> Having to do with the slow metabolizers...I'm not sure I grasp the explanation but maybe other folks are smarter than I am and do. If a person isn't metabolizing a drug how would it be available in the body to induce an effect? It seems like they would notice little or no effects. I have heard of drug sensitive folks who need less but this drug takes a while to do the work it's supposed to do.
Once the drug is in your system it does not stay forever. Most drugs get borken-down(metabolized) into simpler parts that mostly have no effect.If someone is a poor metabalizer, the drug stays around longer and build up to higher levels.
The big point is that people don't know how well they metabalize, so it is a good idea to start slow so that they won't reach too high a level.
The trade off is that it will take longer to get a good reaction for normal metabolizers as they slowly increase the dosage. On the other hand if people start off at a higher doseage and get a lot of side-effects, these people often won't even try again at a lower dosage.
poster:paulk
thread:133458
URL: http://www.dr-bob.org/babble/20030411/msgs/219820.html