Posted by pelorojo on April 22, 2003, at 16:23:12
In reply to Re: Highest possible *single dose* of Neurontin? » Ame Sans Vie, posted by Viridis on April 22, 2003, at 1:40:39
Note also that Neurontin inhibits its own absorption, so rising doses involve diminishing returns:
From: RKolli@aol.com (Ravi Kolli, MD) Date: Tue, 17 Nov 1998 23:43:06 EST Subject: Gabapentin dosage
I wanted to elaborate a bit. Gabapentin (Neurontin) is absorbed via the neutral amino acid transport process, which is saturable. So:
for a single dose of (mg) the bioavailability is about (%)
100 80
300 70
600 50
900 40
and so on at a diminishing rate. That is why any single dose > 600 mg will result in less drug being absorbed and the dose has to be divided. I hope this explanation makes sense.
poster:pelorojo
thread:220935
URL: http://www.dr-bob.org/babble/20030417/msgs/221521.html