Posted by freedom2001 on April 29, 2003, at 0:24:18
A transgenic model of comorbid Tourette's syndrome and obsessive-compulsive disorder circuitry
EJ Nordstrom, FH Burton
Mice were genetically engineered to mimic the heightened regional brain activity thought to be associated with Comorbid Tourette's Syndrome and Obsessive-Compulsive Disorder (TS+OCD). These mice exhibit not only OCD-like behaviors but TS-like ticcing, including increased tic number, complexity and flurries, more severe tic flurries in males, juvenile onset of ticcing, ability to temporarily suppress ticcing, and tic responsiveness to a therapeutic TS+OCD drug, clonidine.
"This supports a cortical-limbic glutamatergic neuron (CGN) 'hyperactivity' model of TS+OCD, which may lead to new anti-glutamatergic drug treatments for this human disorder."
poster:freedom2001
thread:223065
URL: http://www.dr-bob.org/babble/20030423/msgs/223065.html