Posted by Larry Hoover on May 17, 2003, at 11:39:44
In reply to Mitral Valve Prolapse and ADs, posted by Babysnakes on May 17, 2003, at 11:12:44
> Curious if anyone out there has Mitral Valve Prolapse or Dysautonomia and tried various ADs, especially SSRIs.
>
> It occurs to me that I've been hyper sensitive to stimulants of any kind since my early to mid twenties. It turns out I have MVP. Had to drop coffee first, then tea and finally I can only tolerate a Coca Cola now and then.
>
> My experience with Wellbutrin was predictably bad because of the stimulation and now I'm having trouble adjusting to Prozac. Although it seems to be getting a little better (up to 20 mgs) and on week two. Still intend to give it at least a months trial. Any thoughts from any MVP fellow sufferers or anyone else super sensitve to stimulants.You may be suffering from low magnesium levels. Stimulant sensitivity should diminish with magnesium, as well.
Am J Cardiol 1997 Mar 15;79(6):768-72
Comment in:
Am J Cardiol. 1997 Oct 1;80(7):976.
Clinical symptoms of mitral valve prolapse are related to hypomagnesemia and attenuated by magnesium supplementation.Lichodziejewska B, Klos J, Rezler J, Grudzka K, Dluzniewska M, Budaj A, Ceremuzynski L.
Department of Cardiology, Postgraduate Medical School, Grochowski Hospital, Warsaw, Poland.
Mitral valve prolapse syndrome (MVP) is a frequent disorder characterized by a number of complaints which lessen the quality of life. The pathogenesis of MVP symptoms has not been fully elucidated. Hyperadrenergic activity and magnesium deficiency have been suggested. This study was designed to verify the concept that heavily symptomatic MVP is accompanied by hypomagnesemia and to elucidate whether magnesium supplementation alleviates the symptoms and influences adrenergic activity. We assessed serum magnesium in 141 subjects with heavily symptomatic primary MVP and in 40 healthy controls. Decreased serum magnesium was found in 60% of patients and in 5% of controls (p <0.0001). Patients with low serum magnesium were subjected to magnesium or placebo supplementation in a double-blind, crossover fashion. Typical symptoms of MVP (n = 13), intensity of anxiety, and daily excretion of catecholamines were determined. After 5 weeks, the mean number of symptoms per patient decreased from 10.4 +/- 2.1 to 5.6 +/- 2.5 (p <0.0001), and a significant reduction in weakness, chest pain, dyspnea, palpitations, and anxiety was observed. Increased noradrenaline excretion before and after magnesium was seen in 63% and 17% of patients, respectively (p <0.01). Mean daily excretion of noradrenaline and adrenaline was significantly diminished after magnesium. It is concluded that many patients with heavily symptomatic MVP have low serum magnesium, and supplementation of this ion leads to improvement in most symptoms along with a decrease in catecholamine excretion.
poster:Larry Hoover
thread:227225
URL: http://www.dr-bob.org/babble/20030514/msgs/227232.html