Posted by Angel Girl on May 19, 2003, at 15:46:53
In reply to Re: Depakote / Topomax » Angel Girl, posted by Ritch on May 19, 2003, at 9:45:25
>
> I *believe* that Topamax is in Phase III trials for acute mania (that's from memory though!), which would give it the same FDA indication as Depakote. There have been some isolated posts about it triggering hypomania here, though, so it may not be as potent an antimanic as Depakote or Lithium. Also, TOP has a nasty tendency to cause cognitive blunting and memory problems-sometimes these don't fade for some people. For this reason it needs to be titrated up slowly. Given that, you might be better off *cross-tapering* the Depakote with the Topamax, i.e., dropping the Depakote to 1000mg and adding Topamax, and seeing how you tolerate it and how well it works for you. You might find that both meds work quite well, but at lower doses. Weight gain on Depakote is dose-dependent.Ritch
Thanks for your input. I should've been more explicit. Tapering the 2 drugs is the method that has been discussed between my pdoc and myself. I've read through the archives and read that if the TOP is introduced and increased SLOWLY that cognitive dulling may be avoided. I hadn't found any posts that referred to TOP triggering hypomania.
Thanks again for your input.
Angel Girl
poster:Angel Girl
thread:227558
URL: http://www.dr-bob.org/babble/20030514/msgs/227706.html