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Re: Xanax is Different--Might have AD effect

Posted by SLS on May 27, 2003, at 7:25:07

In reply to Xanax is Different--Might have AD effect » JackT, posted by Jack Smith on May 26, 2003, at 18:16:49

> > I was wondering if anyone had some opinions on these two benzos specifically for social phobia.
>
> Xanax seems to have a mild AD effect.

Hi.

There is a drug known as adinazolam (Deracyn) that is a benzodiazepine and used almost exclusively for treating depression elsewhere in the world. It is most similar structurally to alprazolam (Xanax); both of them being triazolobenzodiazepines. In addition to being a partial agonist at benzodiazepine receptors, adinazolam has been reported to promote the release of both norepinephrine (NE) and serotonin (5-HT). There are only three available triazolobenzodiazepines: alprazolam, adinazolam, and triazolam. Perhaps all three possess antidepressant properties, although I have never seen any such claim made of triazolam (Halcion).

I tried using adinazolam about 15 years ago when it was being investigated in the US for depression. It did not work for me, but it did for many others to the surprise of the investigators. I felt absolutely no sedative or anxiolytic properties.

 

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