Posted by MB on May 29, 2003, at 20:29:55
In reply to Re: HPA, Atypicals and Opiates?, posted by davpet on May 28, 2003, at 12:47:45
Hmmm, yeah, that makes sense. Is that why they down-taper your doses after a Prednisone cycle? The whole negative feedback mechanism inherent in the HPA axis seems like it would make modulating this system difficult! Also, I guess another question is: which is primary, the physiochemical dysfunction of the brain, or the dysfunction of the HPA. It's like the "chicken and egg" riddle. Maybe we can't separate the endocrine system from the nervous system as strictly as it would seem. Glands have receptors for monoamines, and the brain has receptors for hormones, and the whole thing is so confusing *I* sure as heck can't figure it out...
MB
> MB i think Prednisone augmentation would only be useful in the short term , in the long term it would then cause further down-regulation of the Glucocorticoid-Receptors (GR) and make matters worse
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> (I've seen this when my dog had cancer they gave her Prednisone her swelling virtually disappeared and then rebounded much worse 10 days later)
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poster:MB
thread:228381
URL: http://www.dr-bob.org/babble/20030525/msgs/230063.html