Posted by McPac on July 1, 2003, at 1:45:25
In reply to Re: Celiac disease and depression, posted by bookgurl99 on July 1, 2003, at 1:10:33
From: RBHOGGAN@cbe.ab.ca
Date: Tue, 04 Jun 1996 00:11:21 -0700 (MST)
Subject: DepressionThere is a tremendous volume of information that ties depressive illness
to gluten intolerance.In 1976, Dr. Richard Mackarness published his book "NOT ALL IN THE MIND"
through Thorsons of Hammersmith, London, and San Francisco. He repeatedly
demonstrates that food allergies, especially in gluten allergies or
intolerance, behavioural and psychiatric symptoms are common.Cooke & Holmes, in their book, "COELIAC DISEASE" published by Churchill
Livingstone, New York, 1984, they repeatedly cite depressive illness as
THE MOST COMMON symptom of gluten intolerance. They also cite a study
that demonstrated that newly diagnosed celiacs recover from their
depressions much more quickly when their diets are supplemented with
vitamin B6. Of course, malabsorption of fat soluble vitamins is legion in
gluten intolerance, but all vitamin absorption is a problem. The jejunal
microvilli are damaged such that they do not absorb fats (and therefore
fat soluble vitamins) very well, but B6, B12, and folic acid deficiencies
that virtually always accompany gluten intolerance, are all involved in
neurotransmission.Do not be misled. Because fats can be made from other foods, the
malabsorption associated with gluten intolerance need not suggest an
underweight condition in our calorie rich diets.Dr Kozlowska, in her article "Evaluation of Mental Status of Children
with Malabsorption Syndrome After Long-Term Treatment" published in
"PSYCHIATRIA POLSKA" 25/2 Mar/Apr. 1991, identified fully 71% of the
children they studied as having psychiatric disturbances.In "PRINCIPLES OF ANATOMY AND PHYSIOLOGY" 6th ed. by Tortora &
Anagnostakos, Harper & Row, New York, 1990, the authors make the very
clear statement:
"you will also learn that certain disorders such as Parkinson's disease,
Alzheimer's disease, depression, anxiety, and schizophrenia involve
improperly functioning neurotransmitters."Opioids, of course, will compete for endorphin receptors in the synapses,
thus altering the neurotransmission at synapses where the opioids have
attached.Zioudrou et. al. in "Opioid Peptides Derived From Food Proteins" in
"JOURNAL OF BIOLOGICAL CHEMISTRY" vol. 254, no. 7, page 2446, April 10,
1979, clearly demonstrated that pepsin digests of wheat can form these
opioids in the gut.Husby, et. al. in "Passage of Undegraded Dietary Antigen into the Blood
of Healthy Adults" in "SCAND. JOURNAL OF IMMUNOLOGY" 22, 1985,
demonstrate how these opioids pass through the intestinal wall, and into
the bloodstream.Paul H. Black, in "Psychoneuroimmunology: Brain and Immunity" in
SCIENTIFIC AMERICAN SCIENCE & MEDICINE, vol. 2, issue 6, p. 16, Nov-Dec,
1995, has shown how opioids may enter the brain through the HPA axis,
thereby bypassing the blood brain barrier.These are just two possible explanations for depression in celiac
disease. There are many more. The point is that such depressions need to
be treated with a gluten-free diet, and vitamin supplementation, where
possible intravenously, because of poor absorption.
I am not a doctor. I am just trying offer an alternative. Please consult
a physician for advice pertinent to your situation. For instance, if her
health permits, you might have her fast for three days. If there is an
improvement, then the problem is quite likely the result of something she
is eating. A physician would be able to determine if she is fit enough to
safely undertake such a fast.I hope that is helpful,
Ron Hoggan
poster:McPac
thread:237849
URL: http://www.dr-bob.org/babble/20030624/msgs/238370.html