Posted by BekkaH on August 2, 2003, at 22:01:17
In reply to Re: cognitive decline impeding life - Mila, posted by Mila S on August 2, 2003, at 16:42:17
Do you remember which antidepressants you combined with stimulants? I wonder whether there might have been some adverse interaction between the stimulants and the particular antidepressants that you took. I mention this because in another post you mentioned your recent illness from a drug combination and your improvement when that drug combination was stopped. Perhaps you have read about the cytochrome P450 liver enzymes, or perhaps your doctor has mentioned them? Many people lack or have deficient versions (called genetic polymorphisms) of liver enzymes that are critical for metabolizing psychiatric drugs and other drugs. Some drugs, when taken together, compete for the same liver enzymes. And if that isn't complicated enough, many drugs inhibit the activity of the liver enzymes that are necessary for the metabolism of other drugs. This makes drug cocktails very difficult, and often dangerous, for those of us with genetic polymorphisms. I wonder whether this might be the cause of some of your difficulties.
poster:BekkaH
thread:246353
URL: http://www.dr-bob.org/babble/20030802/msgs/247679.html