Posted by Larry Hoover on August 11, 2003, at 17:05:09
In reply to Larry Hoover, posted by McPac on August 11, 2003, at 15:58:42
> Lar,
> you mentioned in another post (couldn't find it) that lithium and inositol can have a negative interaction? Could you please elaborate on that, as I do take both...THANKS!!!!!!I don't recall the exact nature of the thread you're referring to, but this is what I was talking about:
Nature. 2002 May 16;417(6886):292-5.
A common mechanism of action for three mood-stabilizing drugs.Williams RS, Cheng L, Mudge AW, Harwood AJ.
Intracellular Signalling Group, MRC Laboratory for Molecular Cell Biology, University College London, Gower St, London WC1E 6BT, UK.
Lithium, carbamazepine and valproic acid are effective mood-stabilizing treatments for bipolar affective disorder. The molecular mechanisms underlying the actions of these drugs and the illness itself are unknown. Berridge and colleagues suggested that inositol depletion may be the way that lithium works in bipolar affective disorder, but others have suggested that glycogen synthase kinase (GSK3) may be the relevant target. The action of valproic acid has been linked to both inositol depletion and to inhibition of histone deacetylase (HDAC). We show here that all three drugs inhibit the collapse of sensory neuron growth cones and increase growth cone area. These effects do not depend on GSK3 or HDAC inhibition. Inositol, however, reverses the effects of the drugs on growth cones, thus implicating inositol depletion in their action. Moreover, the development of Dictyostelium is sensitive to lithium and to valproic acid, but resistance to both is conferred by deletion of the gene that codes for prolyl oligopeptidase, which also regulates inositol metabolism. Inhibitors of prolyl oligopeptidase reverse the effects of all three drugs on sensory neuron growth cone area and collapse. These results suggest a molecular basis for both bipolar affective disorder and its treatment.
Lar
poster:Larry Hoover
thread:250089
URL: http://www.dr-bob.org/babble/20030807/msgs/250097.html