Posted by BekkaH on August 18, 2003, at 0:18:20
In reply to Is there such a thing as a serotonin antagonist?, posted by DSCH on August 18, 2003, at 0:06:47
Well, how about Tianeptine? Tianeptine causes serotonin reuptake (i.e., it does NOT inhibit the reuptake).
Medicines that increase dopamine can cause a decrease in serotonin and vice versa.
I'm not sure that serotonin is the problem, however. I think the problem lies with the mechanism of action of the ssri's in particular. There are other drugs, like Trazodone and Nefazodone, for example, that affect serotonin without the dreaded apathy, fatigue and prostration caused by ssri's. Also, in my experience, the most selective of the ssri's (Celexa/lexapro) caused the worst apathy and amotivational syndromes.
poster:BekkaH
thread:251736
URL: http://www.dr-bob.org/babble/20030812/msgs/251739.html