Posted by btnd on August 25, 2003, at 1:23:15
In reply to Re: Prevention of long-term negative effects?, posted by stjames on August 24, 2003, at 16:31:37
> For example, long-term use of amphetamines I believe could lead to dopaminergic and noradrenergic inadequacy (correct me if I'm wrong on any of this).
IMO not quite so. Dopamine system is pretty robust when it comes to rebuilding itself (unlike the serotonin). Unless you use high doses of amphetamine-type stimulants, there is no need to worry about dopamine toxicity or inadequacy over time. Although it wouldn't hurt to use anti-oxidants: alpha lipoic-acid, green tea extract, vit.E - anything except Vit.C which, via unknown mechanism, counteracts amphetamine action.
When it comes to norepinephrine - even high doses of amphetamine are not toxic to norepinephrine and its' storage site. Norepinephrine levels change when the drug is working - amphetamines release it and inhibit its reuptake.
>And Dexedrine is really the only one I'm >concerned about, actually.I wouldn't worry about Dexedrine more than about Adderall/Desoxyn. They are pretty much all amphetamines (desoxyn - methamphetamine) with the same method of action, same effects and side-effects in therapeutic doses.
> I would not expect this to happen unless your were
> taking amphetamine at levels of abuse; at least an order a magnitude higher.I agree 100%.
poster:btnd
thread:253550
URL: http://www.dr-bob.org/babble/20030823/msgs/253770.html