Posted by loolot on September 14, 2003, at 22:22:39
In reply to Disappointing news re selegiline patch, posted by Iansf on September 14, 2003, at 18:09:17
What a drag.I was kind of counting on this
Sounds like in the Comments section there is a little bit of doubt about the way the study was conducted? Or about some of the findings in general, maybe.>
> COMMENTS
> 1. It is curious that a study of this size was published by a single author. It is also curious that the response rates were low; in most studies of this nature, the placebo response rate, itself, is in the 40-50% range.
>
> 2. An earlier study (Bodkin and Amsterdam, 2002) reported more encouraging results with the selegiline transdermal delivery system; the reason for the relative failure of the present study is unclear.
>
> REFERENCES
> Amsterdam JD. A double-blind, placebo-controlled trial of the safety and efficacy of selegiline transdermal system without dietary restrictions in patients with major depressive disorder. J Clin Psychiatry 2003; 64: 208-214.
>
> Bodkin JA, Amsterdam JD. Transdermal selegiline in major depression: a double-blind, placebo- controlled, parallel-group study in outpatients. Am J Psychiatry 2002; 159: 1869-1875.
>
poster:loolot
thread:260024
URL: http://www.dr-bob.org/babble/20030912/msgs/260071.html