Posted by JonW on September 25, 2003, at 19:15:36
In reply to You've convinced me » Jon21, posted by NikkiT2 on September 25, 2003, at 15:02:43
> That there is NO way I could try this drug!!!
>
> No way I could live without macaroni cheese, and pizza *lol*Hi Nikki,
You may not want to try this drug, but it should be because it appears somewhat less potent than other drugs, not for fear of an interaction with cheese. I urge you to search PubMed, and you will find that dietary tyramine is not a major concern with moclobemide. My experiences certainly confirm this. I have really tested moclobemide when it comes to dietary restrictions and drug-drug interactions. I've combined it with everything! I've devoured huge amounts of cheese without any problem. I love pizza, and eat it all the time. The only time I had an issue, was once I combined a lot of alcohol (I was drunk of my ass) while on aniracetam (effectively a stimulant) and smoked a lot of really good weed. I had a hypertensive crisis (wasn't I asking for one?), but it resolved itself within minutes. It was still very scary. Since then I tested different combinations of those three substances, aniracetam/weed/alcohol, to determine the problem. It turned out that aniracetam in combination with weed don't agree with me while on moclobemide. I've since combined huge amounts of weed and alcohol without aniracetam, and have never had a problem. I always took my blood pressure, and it was never of concern. I have since stopped aniracetam, not so I could smoke weed :) on moclobemide, but because it was making me irritable and agitated as stimulants tend to do that to me. By the way, I don't smoke or drink anymore as it seems to get in the way of the drug working... not to mention, getting anything done :)
I take 450mg of moclobemide. Have essentially no side-effects, and have had a response comparable to that of the SSRIs. There is reason to avoid moclobemide. It certainly appears to work for fewer people than other drugs. I mean, that's the impression you get. But search the web, search PubMed... you will find very little evidence, if any, of the lack of dietary restrictions causing problems. The only things to really avoid are MDMA, SSRIs, stimulants, etc. I've never had a problem with decongestants. If I were you, I'd give it some more thought... I personally have had an excellent response along with a handul of others, and without side-effects. Take a poll here and other places... inquire about peoples experience eating cheese while on moclobemide. I would be surprised if you find very many people, if any, who had problems. I'd even ask, Jon21. It doesn't sound as though he's had a problem with it, either. I think he's wise to be conservative, but in light of the evidence I believe his suggestion is overly cautious. I've pasted an abstract at the bottom of this post you may find of interest.
Good Luck,
Jon :)--------------------------------------------------
Comparison of the pressor effect of tyramine after treatment with phenelzine and moclobemide in healthy male volunteers.Simpson GM, Gratz SS.
Department of Psychiatry, Medical College of Pennsylvania 19129.
This study was conducted to establish the safety, tolerability, side effects, and pressor effects of tyramine on subjects treated with moclobemide, a short-acting reversible and preferential monoamine oxidase inhibitor, and to compare these responses with the responses of subjects treated with phenelzine. Twelve healthy male volunteers participated. An oral tyramine sensitivity test was performed on all subjects 24 hours before the start of a 28-day open-label treatment with phenelzine or moclobemide. A tyramine challenge was performed on day 28 on four subjects treated with phenelzine. The mean dose of oral tyramine required to increase systolic blood pressure by 30 mm Hg was 15 mg. The mean dose of tyramine that produced a clinical response (day 28) in subjects treated with moclobemide was 240 mg. No subject receiving moclobemide responded clinically on day 31 after receiving hourly doses of 20, 40, 80, 160, and 320 mg, respectively. These findings suggest that moclobemide may be used without stringent dietary precautions.
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poster:JonW
thread:263231
URL: http://www.dr-bob.org/babble/20030923/msgs/263311.html