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Re: Anyone ever combine MAOI + Remeron ??? » cybercafe

Posted by SLS on November 4, 2003, at 19:27:39

In reply to Re: Anyone ever combine MAOI + Remeron ???, posted by cybercafe on November 4, 2003, at 15:59:16

> > I'm considering asking my doctor to look into the possibility of combining Parnate + Remeron. I have never heard of this being done, but I am getting pretty desperate.

> > Any feedback would be welcome!

> sounds like serotonin syndrome ... i wouldn't do it ... from what i know now


Thanks, Cybercafe.

Did you experience an adverse event involving serotonin syndrome?

I would like to remain cautious on this one. However, from a simplistic model, I don't think serotonin syndrome should be a problem. From what I've read, Remeron does not inhibit the reuptake of serotonin, nor does it stimulate serotonergic receptors. It actually blocks the stimulation 5-HT2 and 5-HT3 receptors, which might actually protect from the development of the syndrome. I am more concerned with Remeron's ability to block presynaptic NE alpha2 autoreceptors, in that it might act synergistically with an MAOI to increase levels of synaptic NE and cause a rise in blood pressure.


- Scott

 

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