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Q for Salty Dog especially re withdrawal SEs » Salty_Dog

Posted by zinya on November 8, 2003, at 18:02:34

In reply to Re: Anyone had success on Effexor XR? » clb149, posted by Salty_Dog on November 3, 2003, at 22:49:43

hi S.D.
about a week ago, while i was still on hiatus from checking in here for a while, mercedes relayed to me the following which i guess came from a post of yours, as noted here, concerning something you'd gotten from somewhere listing SEs from "abrupt withdrawal" (see below) ... If i understood correctly, do you recall where you got this info from? i'd be interested if you still have a website or something for it...

Secondly, i've just described in some detail in a post replying to KimD my latest symptoms and situation so i won't repeat here but if you read that post you'll see where i'm at now, which seems to QUITE contradict the notion that these SE's (and particularly the paresthesias) only result from *abrupt* withdrawal. Nobody could POSSIBLY be doing more gradual w/d than i am, but i'm rather totally hamstrung by paresthesias responses which are hard to account for as being triggered without taking the Effexor w/d into the picture...

and thanks for having shared this originally in what appears to have been a post of yours from a month ago...

good luck to you and congrats on the job!
zinya

Posted by Salty_Dog on October 6, 2003, at 17:06:37

In reply to Re: Effexor side effects - heart palpitations <http://www.dr-bob.org/babble/20031004/msgs/265901.html>; , posted by darthwribar on October 6, 2003, at 8:16:40

I have found a statement concerning arrhythmia and angina pectoris (chest pain) in < 1% of the trial victims. I also found a direct statement concerning withdrawl:

Abrupt Discontinuation of EFEXOR-XR: Discontinuation symptoms have been assessed both in patients with depression and in those with anxiety. Abrupt discontinuation, dose reduction, or tapering of venlafaxine at various doses has been found to be associated with the appearance of new symptoms, the frequency of which increased with increased dose level and with longer duration of treatment. Symptoms reported included agitation, anxiety, confusion, dry mouth, fatigue,
paresthesias,
vertigo, hypomania, nausea, vomiting, dizziness, headache, diarrhoea, sleep disturbance, insomnia, sweating and nervousness. Where such symptoms occurred, they were usually self-limiting, but in a few patients lasted for several weeks. Discontinuation effects are well known to occur with antidepressants. There is also a report of a withdrawal syndrome, confirmed by two challenges in a 32 year old woman who had received venlafaxine 300 mg daily for 8 months. It is therefore recommended that the dosage of EFEXOR-XR be tapered gradually and the patient monitored. The period required for discontinuation may depend on the dose, duration of therapy and the individual patient (See DOSAGE AND ADMINISTRATION).


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