Posted by SLS on November 19, 2003, at 13:39:18
In reply to IS THIS REALLY ACURATE?? Ratio of Sero / NE ??????, posted by smittay17 on November 19, 2003, at 8:46:27
> is there somewhere online where it says the ratio of Sero/NE in Imipramine online>?
>
> i have to change my medicine tomorrow and i really, really need to show my doctor this.
>
> he has no clue and i could really use some help? anyone please?
Here is a website that presents the binding affinities of many drugs. Just use the drop-down menu to find the drugs you are interested in and then review the numbers given for NE and 5-HT transporters. The lower the number, the more it inhibits reuptake. However, be advised that these numbers are being generated using methods that don't always reflect what goes on in the living brain. I would say that nortriptyline would be preferable to desipramine if you are looking for increasing serotonergic activity. Unfortunately, getting the dosage right with nortriptyline can be tricky and sometimes requires blood tests. Most people do well on 75mg.Good luck.
- Scott
poster:SLS
thread:280491
URL: http://www.dr-bob.org/babble/20031116/msgs/281277.html