Posted by linkadge on November 23, 2003, at 17:12:48
In reply to Re: Zyprexa pharmacological properties.., posted by LostBoyinNC34 on November 22, 2003, at 17:16:01
Does the guy who made the previous post know anything at all ???
Antipsychotics, block specific receptors, and in doing so, can leave more dopamine for other receptors, such as the D3,D4 receptors which are involved in novelty and BDNF expression. As well the atypicals, block the ht2a receptor, which again leaves more serotonin for other receptors. This is also how mirtazapine works.I may or may not be correct, but I believe the atypicals have some specific action at the 5ht1a receptor, which may acount for some of their antidepressant effects.
Adding a low dose of an atypical, is quite often done. Infact the addition of an atypical to an SSRI, has been shown to increase dopamine, and norepinephrine in the prefrontal cortex.
The mechanizm for this augmentation effect is not clearly understood.
Linkadge
poster:linkadge
thread:282368
URL: http://www.dr-bob.org/babble/20031121/msgs/282931.html