Posted by ace on December 9, 2003, at 18:54:47
In reply to Re: Nardil + 50mg Amisulpride + 2.5mg Zyprexa safe???, posted by SLS on December 9, 2003, at 7:36:25
> > I'm thinking of adding on 2.5mg Zyprexa to my current combo of 90mg Nardil (the BEAST!!) and 50mg Amisulpride.
> >
> > I would do this for a short period- a month or two at very most. Who deems such a move by Mr. Ace as safe?????????
> >
> > Thankyou my lovely friends..........
> >
> > Ace.
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> I cannot think of anything that would contraindicate such a combination.Me either- a serotonin syndrome is not a possibility nor is a hypertensive reaction.
However, I am not a pharmacologist MD. It is possible that no one has tried this combination to be able to report on its safety.Yeah, I mean, I can hardly get literature on any MAOI combos, let alone one with this degree of...sahll I say 'innovation'!
Because the degree of uncertainty is so high, I suggest proceeding cautiously - low and slow.Oh yeah, Just the 50mg Amsidulpride and no higher than 2.5 nocte with the Olanzapine. I will be extra vigilant to s/effects and any new untoward reaction. Frankly though, apart from added appetite stimulation and extra sedation, I see the prospect of any new s/effects quite low.
> I noted your comment in another thread regarding the possibility that higher dosages of Zyprexa are counterproductive. I don't know for sure, but that just doesn't sound right to me. 5mg seems like a good dosage to be sure to glean the optimal antidepressant effect from Zyprexa. I found that Abilify produced a better, albeit brief, antidepressant response. I have no idea as to how well it would work for OCD.
Scott- this is always something that intrigued me. When I first started Zyprexa 2.5mg quickly set Nardil off in a great way- It really kicked in. However, after nearly 3 weeks of raisng my Olanzapine (up to 7.5mg at one point) I suffered an intractable depression. Ceasing Zyprexa did not help. Highering Nardil did not. I had to LOWER Nardil along with ceasing Zyprexa to recover and regain some AD effect from Nardil.A month later I gave Zyprexa another shot to regain the Nardil AD qualities. This time It didn't work, and further, after being at 2.5mg for three weeks, i raised to 5mg for just ONE day...the next day I suffered depression, and had to stop Zyprexa and lower Nardil.
This is weird. I really want your opinion on this. At 5mg Zyprexa would be acting as more as a 5HT and DA AGONIST right? Someone suggested that the depression stemmed from upregulation of the receptor in response to 5HTa receptor blockade.
I'm not sure- did too much 5HT cause the depression? Was Zyprexa acting as an ANTAGONIST for DA and 5HT, thereby negating Nardil's actions?
Help me out!
BTW, good to see you posting regularly again dude! You've had a hard time lately?
Ace..................
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> - Scott
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poster:ace
thread:287885
URL: http://www.dr-bob.org/babble/20031208/msgs/288117.html