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Re: ...AND WHERE THE HECK IS BROFAROMINE??

Posted by MARKED on January 17, 2004, at 15:55:12

In reply to ...AND WHERE THE HECK IS BROFAROMINE??, posted by Rick on September 20, 1999, at 3:31:03

This abstarct was very welcoming to read as well, in relation to Brofaromide/Moclobemide clinical studies:
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2001000400032&lng=en&nrm=iso&tlng=en

Hope all get the treatment they are searching for.


> > HI,
> >
> > I HAVE TERRIBLE "SOCIAL PHOBIA." MY PSYCHDOC HAS
> PRESCRIBED NARDIL AND KLONPIN. BOTH ARE VERY
> EFFECTIVE, BUT THE KNOLONPIN MAKES ME DROWSY. THE
> PURPOSE FOR USING KLONOPIN AS AN ADJUNCT, I'M
> TOLD, IS TO SUPPLEMENT THE NARDIL. THAT IS,
> NARDIL, FIRST, AND THEN LOW STEADY STATE DOSE OF
> KLONOPIN. MY PROBLEM IS NARDIL HAS CAUSED ME TO
> GAIN OVER 20 POUNDS, AND HAS ALSO CAUSED 100%
> ANORGASMIA. HAS ANYONE TRIED ANYTHING ELSE THAT
> WORKED BETTER THAN NARDIL, WITHOUT THE SIDE
> EFFECTS. MY SEARCH OF MEDLINE INDICATES THAT THE
> SSRI'S AND THEIR COUSINS GENERALLY ARE NO BETTER
> THAN RELIEVING 40-45% OF THE SYMPTOMS, COMPARED
> WITH PLACEBO EFFECT OF 20-25%. I DON'T WANT THE
> SAME PROBLEMS ASSOCIATED WITH SSRI'S (SEXUAL
> DYSFUNCTION), WITH SUCH A LOWER LEVEL OF EFFICACY
> COMPARED TO NARDIL. BASICALLY, THEY SEEM TO OFFER
> ALL THE NEGATIVES WITHOUT THE BENEFIT, FOR SOCIAL
> PHOBIA, THAT IS. I HAVEN'T HEARD ANYTHING ABOUT
> REBOXETINE (IN TREATING SP), WHICH IS SOON TO BE
> RELEASED IN THE US (4TH QTR 1999). ALSO,
> UNDERSTAND GABAPENTIN AND ONDANSETRON DIDN'T MAKE
> IT THROUGH STAGE III TRIALS DUE TO LACK OF
> EFFICACY.
> >
> > THERE HAS TO BE SOMETHING! BY THE WAY,
> PARNATE'S EFFICACY IN TREATING SP IS EQUIVOCAL.
> >
> > ANY IDEAS?????????????????
>
> --------
>
> Contrary to initial reports, the reversible,
> A-selective, and thus "gentle" (no food
> restrictions or nasty side effects) MAOI
> Moclobemide has recently been shown to be fairly
> ineffective for Social Phobia. Yet tests as
> recent as 1997 by Ciba-Geigy show Brofaromine,
> another reversible, A-selective gentle MAOI to be
> VERY effective for SP (e.g., see Medline 1997
> study).
>
> So why isn't Brofaromide being manufactured
> anymore?? At least Moclobemide (Manerix) can be
> bought in Canada or mail-ordered to the U.S., but
> why wouldn't Ciba withold Brofaromide just as
> Social Phobia/Anxiety is finally being recognized
> as a HUGELY prevalent mental disorder, and
> garnering scads of press...not to mention the
> drug's base use as an AD. Is someone asleep at
> the wheel and denying the Social Phobics and MAOI
> that actually works AND won't make them give up
> cheese or sex? What gives? Geez, someone can
> make MONEY from this, no??


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poster:MARKED thread:11383
URL: http://www.dr-bob.org/babble/20040114/msgs/302062.html