Posted by john1022 on January 21, 2004, at 18:16:19
In reply to Re: Lithium is making me feel WORSE! » john1022, posted by SLS on January 21, 2004, at 18:12:37
here is what I found on the internet...
L. Orotate and dopamine release
Lithium is most famous for treatment of manic-depressive disorders. At high doses lithium can depress dopamine release.
Adaptive changes in the rat dopaminergic transmission following repeated lithium administration.
Dziedzicka-Wasylewska M, Mackowiak M, Fijat K, Wedzony K. Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland.
In the present study the alterations in the contents of dopamine (DA) and metabolites, as well as in the levels of mRNA coding for DA receptor D2, were determined in the rat striatum (STR) and nucleus accumbens septi (NAS), in correlation with the duration of lithium administration. Single or subchronic (3 days) administration of lithium produced less consistent effects as far as the levels of DA and metabolites are concerned; however, following 7 or 14 days of lithium administration, the DA release from terminals was significantly attenuated and the effect was more pronounced in NAS. After the same time of treatment, the increase in the levels of mRNA coding for the D2 receptor was increased; this might be interpreted as an adaptive change to the decreased dopaminergic transmission following the prolonged administration of lithium.
(which tends to flatten elevated moods), while at lower doses it can stimu
poster:john1022
thread:303825
URL: http://www.dr-bob.org/babble/20040118/msgs/303866.html