Posted by scott-d-o on January 21, 2004, at 21:15:49
In reply to Re: Dopamine system out of whack? » scott-d-o, posted by jerrympls on January 21, 2004, at 18:53:45
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> Hey Scott
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> I've been on immediate release Ritalin (each dose only lasted a couple hours) and the SR version (wasn't much difference compared to the immediate release). I've also been on Adderall immediate release - which wasn't too bad but still ups and downs AND it eventually made me more apathetic even tho it helped with concentration - so it's interesting you bring up the differences between the mechanisms of action and the dopamine transport system! The Dexedrine Spansules (extended release) have always worked well. I've wanted to try Concerta because I've heard it lasts all day and doesn't give you so much of a "crash." I hope you share your experiences if you eventually go on it!
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> Thanks for your reply!
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> JerryyI have heard that Ritalin SR doesn't last much longer than the immediate release version, which only lasts about 3 hours for me. Adderall immediate-release lasted a bit longer for me, maybe like 5 hours. I am hopeful that Concerta will be the ultimate solution for me; it lasts for about 12 hours.
The pharmacokinetics of Concerta look very promising. It reaches it's peak plasma concentration 6.8 hrs after dosing. If you are interested you can go to this link:
http://www.fda.gov/cder/foi/nda/2000/21-121_Concerta_prntlbl.pdf
Scroll down to page 4 to see a graph of Concerta 18mg vs. Ritalin 5mg TID (4 hrs between doses). Notice how much smoother the Concerta line is in comparison; the Concerta line looks like a bell curve, while the Ritalin IR line is all over the place. Not to mention the convienence of not having to carry your meds w/you all the time.
I should be starting on the med next Monday, most likely starting at 18mg.. I'll let you know how it goes.
scott
poster:scott-d-o
thread:303487
URL: http://www.dr-bob.org/babble/20040118/msgs/303959.html