Posted by zeugma on February 4, 2004, at 19:10:05
In reply to Re: ANYONE TRIED BUSPAR FOR GAD?, posted by Chairman_MAO on February 4, 2004, at 10:25:29
My personal theory is that buspar works a lot better when combined with a noradrenergic-type med (high-dose Effexor, Strattera, TCA) because of its metabolite which is an alpha-2 antagonist and boosts NE transmission. Remeron with effexor is called 'California rocket fuel' and buspar might make a similarly potent combination. It seems that buspirone can actually interfere with an SSRI's effect on 5-HT even as it improves sexual dysfunction (it is a partial agonist and can either raise or lower serotonin levels, depending on whether the levels are high or low to begin with. On an SSRI they would naturally be high.) I doubt any drug company will test this theory now that it's off patent but from the small sample here (n=2) it seems to have some validity.
poster:zeugma
thread:309249
URL: http://www.dr-bob.org/babble/20040204/msgs/309478.html