Posted by aazospiro on February 10, 2004, at 10:57:52
In reply to Re: manerix combined with celexa, posted by stann on February 10, 2004, at 9:38:45
The neurobiological basis for social anxiety disorder remains to be completely elucidated, although the dopamine system is known to be involved.Like many illnesses, a genetic element is involved; SAD being more common in relatives than in the general population. Environmental factors may contribute to social anxiety disorder.
The Monoamine Oxidase Inhibitors are known to be efficacious in treating this disorder. Manerix is a Monoamine Oxidase-A inhibitor, MAO-A being preferentially responsible for degradation of Serotonin & Norepinephrine in brain neurons. On its own, Manerix use does not warrant the diet restrictions of the older non-selective MAOI's Although the serotonin syndrome is a possibility in combination with Celexa, it depends on the dose of each.
Manerix, will probably, initially, make one feel abit more on edge and nervous than normal, but as time goes by, receptor density will adjust and one will start to feel a change.
However, in my experience, I have found that doperminergic antidepresants do a much better job. And it is also prude to initialize therapy with a low dose of beta blockers [propranolol] for at least 2 weeks. This helps greatly with the somatic symptoms of SAD like hand shaking.
If it were up to me I would keep the Manerix at 150 mg twice daily. Add one Wellbutrin 150 mg instead of Celexa and also add propranolol @ 10 mg twice daily for at least 2 weeks.
Learning to cope with and even enjoy social situations is partly a matter of practice, and some people may not receive this kind of practice when growing up. So, as with other anxiety disorders, nature and nurture may intertwine to bring about symptoms of social anxiety disorder.
p.s. BEAR IN MIND THAT YOUR DOCTOR KNOW BEST, AND NO TREATMENT SHOULD BE INITIATED WITHOUT HIS CONSULTATION.
poster:aazospiro
thread:311499
URL: http://www.dr-bob.org/babble/20040210/msgs/311663.html