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Re: NEWS ON THE SELEGILINE PATCH!!!!!!!!!!!!!!!!!!!!!!

Posted by noa on February 20, 2004, at 17:10:41

In reply to Re: NEWS ON THE SELEGILINE PATCH!!!!!!!!!!!!!!!!!!!!!! » SuzyQ1, posted by sb417 on February 20, 2004, at 1:06:36

The problem is (or so I have read) that selegiline at low doses is effective for parkinsons but not for depression. At low doses it is selective for type B MAO sites, but above 10 mg, it is not selective and acts also on type A MAO sites in the body, including the gastrointestinal system. But supposedly the selectivity is very dose dependent and tyramine intake is only considered safe when taking it at 10 mg or less, but at these doses, it hasn't been found to do much for depression.

I think there is also the risk of serotonin syndrome if combining with other meds.


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