Posted by zeugma on March 15, 2004, at 17:14:44
In reply to Re: replacing nortriptyline with remeron? » zeugma, posted by Sad Panda on March 15, 2004, at 10:09:59
> I take Remeron. It's the most potent H1 blocker available. It's nearly double the strength of Doxepin, 10x the strength of Amitriptyline & 50x stronger than Nortriptyline. 15mg is heaps for sleep, a lot of people get by on just 7.5mg. The amount required just for sleep probably means that it doesn't have much affect on any other receptors. If you are looking for H1 + 5-HT2A for sleep, you may be better off with low dose Trimipramine or Doxepin.
>
> Cheers,
> Panda.Panda,
yes, I was thinking along those lines when I saw how powerfully antihistaminic Remeron is, and how steep its side effect profile appears (not much of an improvement on the tertiary amine TCA's). Plus, remeron seems to have a tendency to elevate levels of cholesterol, and even though I am extremely underweight (so much so that i have been pulled off every stimulant I have ever tried within two weeks because of rapid and dangerous weight loss) my cholesterol levels have always been high.
Low dose trimipramine or doxepin are intriguing choices, especially given my favorable response to nortriptyline. trimipramine has weak D2 blocking effects also, mimicking one of buspirone's effects. It is the only TCA devoid of reuptake blocking effects, and might be a good way to go.
>
poster:zeugma
thread:324271
URL: http://www.dr-bob.org/babble/20040313/msgs/324705.html