Posted by SLS on April 16, 2004, at 7:26:13
In reply to Any news on RIMA's? i.e. Moclobemide or others?, posted by cirrus6000 on April 15, 2004, at 23:01:15
In the early 1990s, Roche tried to get moclobemide approved in the US for the indication of social phobia. They halted the project when the clinical investigations they were conducting in the US failed to demonstrate efficacy.
The good thing about moclobemide is that it can make someone feel better almost immediately, usually in the first week and without side effects. It can be energizing and motivating. The bad thing about moclobemide is that it tends to lose efficacy very quickly, necessitating a continual escalation of dosage to maintain the positive antidepressant effect. The therapeutic range of dosages seems to be between 450mg and 900mg. Very few people maintain an improvement at 300mg. Sometimes dosages up to 1200mg are used.
Please bear in mind that moclobemide does work wonderfully for some people. I think this can be said about any antidepressant. I would not want to discourage someone from trying a treatment that might be ideal for them. However, if your depression is chronic, severe, and disabling, it probably makes sense to try one of the irreversible MAOIs sooner than later.
Good luck.
- Scott
poster:SLS
thread:336780
URL: http://www.dr-bob.org/babble/20040412/msgs/336836.html