Posted by zeugma on April 25, 2004, at 10:14:45
http://jpet.aspetjournals.org/cgi/content/full/295/1/382
This study in the discriminative stimulus properties of the K-channel blocker 4-AP says that this class of pharmacological agent has antidepressant-like activity in behavioral models of depression, due to its boosting of amines DA, NE, and 5-HT, as well as ACh. Tomoxetine (atomoxetine, Strattera) partially substituted for 4-AP at doses that ramged from 1.0-30.0 mg/kg in rats, and the authors of this study claim that this is because of its K-channel blocking properties. Doses that are therapeutic in humans are generally 1.2-1.8 mg/kg in normal metabolizers, and in rats the maximum substituition was reached at 17.8 mg/kg, or approx. 10 times the dose per kg that I'm taking. My question is: is it reasonable to think that these properties play any role in humans at therapeutic doses?
poster:zeugma
thread:339833
URL: http://www.dr-bob.org/babble/20040423/msgs/339833.html