Posted by chemist on May 5, 2004, at 14:36:56
In reply to Re: seroquel to geodon ... weight and sleep? » chemist, posted by nmk on May 5, 2004, at 14:07:39
> > hi nicole...a quick perusal of pubmed reveals: yes, elevated trglycerides have been found in patients on zyprexa; one study found that zyprexa use precipitated diabetes mellitus but 5 of the six patients had some risk for diabetes mellitus before the study, and a switch to seroquel resulted in moderation of ``glycaemic control'' in 2 of the 6 patients (yes, a small cohort but valuable information); a study of zyprexa vs. risperidone revealed that the zyprexa group had high triglycerides, low HDL cholesterol levels, high cholesterol:HDL, high apolipoprotein B, smaller LDL peak particle diameters, and higher fasting insulin concentrations than the risperidone group, conclusions that zyprexa altered metabolic profile for increased risk of atherosclerosis (essentialy, they researchers were looking for a link to heart trouble) over those taking risperidone; another found elevated levels of a protein involved with regulation of glucose metabolism and insulin sensitivity in schizophrenic patients on either zyprexa or risperidone. the protein concentration dropped as the zyprexa patients put on weight, and in the risperidol group, the protein concentration remained high regardless of weight gain/loss; another indicates that weight gain on zyprexa was statistically significant vs. risperidone, seroquel, and haldol; another looked at weight gain in smoking/non-smoking schizophrenics who were taking zyprexa or risperidone. in the zyprexa group, smokers/non-smokers gained weight, yet in the risperidone group, smokers gained less weight than the non-smokers, conclusions being that zyprexa offsets the (common) weight loss seen in smokers but risperidone does not, implying that zyprexa does indeed change your metabolic system; another points to weight gain resulting from affinity for H_{1} histaminergic and alpha_{1} adreneergic receptors, in addition to ``changes in insulin sensitivity'' (among others), and they found that metformin was effective in decreasing weight gain associated with atypical anti-psychotics (Curr. Drug Targets, 5:279-299, 2004); another found that hyperglycemia occurs with treatment of only clozapine or zyprexa, and that weight gian came before onset of hyperglycemia in 2/3 of the patients with hyperglycemia. i note that this study was a 7-year long one, and the study group was 86,349 patients in 35 mental institutions, and that the _total_ number of hyperglycemic patients was 9 (nine, not a typo); okay, that's it for this....seems like zyprexa is pretty-well documented to cause alteration of metabolic pathways and maybe (in the one study) metformin can send your system towards the `right'' side...hope this helps, all the best, chemist
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> Chemist,
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> WOW!!!!!!! Thanks for the information. I didn't expect you to do all you have done in regard to researching the literature so I greatly appreciate your help.
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> I work in an educational institution and have access to all of the medical journals. I would like to read some of the journal articles you came across in your discoveries. Does "Curr. Drug Targets" stand for "Current". Are there any other journals that would help me in my quest to better understand the actions of these meds?
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> Again, you have been a wonderful help to me and all the best to you too!
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> Nicole
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hi nicole...sorry, i should have included all the citations from the abstracts i was perusing...Current Drug Targets it is, you are correct. here's what i did to get the abstracts, if you do the same, you will see the reference. so: go to www.pubmed.org and in the white box near the top type in the word olanzapine. then you can start scrolling, and if your institution has online access to the journals, you can keep clicking and download the pdf or simply read the article on-line....a few of the journals that came up were American Journal of Psychiatry, Journal of Affective Disorders, Journal of Clinical Psychiatry, Journal of Clinical Psychopharmacology, Journal of Psychopharmacology, Schizophrenia Research, and Current Drug Targets.....hope this helps, let me know if i steered you right or wrong....all the best, chemist
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