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Re: Anxiety-Inderal versus atenolol » Kon

Posted by Questionmark on May 9, 2004, at 3:09:23

In reply to Anxiety-Inderal versus atenolol, posted by Kon on May 8, 2004, at 22:47:09

> I've been trying to find a drug that would lower my benzo dose when I do presentations/formal public speaking. I end having to use such a high dose of benzo that it sometimes intereferes with my thought processes. Have tried atenolol (up to 100 mg) to no avail. Alone it didn't do much and when combined with benzo, I felt the same as taking benzo alone. Has anybody compared the effects of atenolol versus inderal?

i have not, but from reading a small number of comments on one or both, i get the impression that Inderal is better for specific/situational anxiety than atenolol for some reason. And this is after previously wanting to try atenolol instead of Inderal because of the former's [almost?] complete lack of CNS effects-- thereby having less cognitive and affective effects.

>Are there any reasons why inderal might work where atenolol hasn't? Thanks

Maybe it is becAUSe of the fact that Inderal crosses the blood-brain barrier to some extent that it is more effective-- maybe some CNS antagonism (even if minute) of NE beta receptors has additional anti-anxiety results than would JUST peripheral effects alone. The primary effects of Inderal are still definitely peripheral, but maybe the minor CNS actions are somewhat important as well. i have no idea, i'm just guessing. This is probably incorrect. But regardless, propranolol (Inderal) seems to be the most commonly efficacious anti-anxiety beta-blocker on the market (though i could be wrong about that too).


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