Posted by florence on May 10, 2004, at 19:51:51
In reply to Re: Does Sonata/Amb.act on the same GABA as Klonopin? » florence, posted by jodeye on May 10, 2004, at 15:48:57
> > > I had succes with provigil for over 2 years; most of the time 50-100 mgs was enough. Now, I have tried up to 250 with not much improvement.
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> I have heard testimonials that NMDA antagonists can prevent stimulant tolerance. I can only wonder if they might prevent Provigil tolerance as well?
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> > > What is zopicom (sp.?).
>
> Zopiclone (imovane(tm)) is what I call one of the Z-drugs... Ambien, Sonata, Imovane -- they all start with the letter Z. I think zopiclone has a longer effect than either Ambien or Sonata. It is a french molecule that can be obtained from Canada with a US doctors prescription. Under $20 a month. You should be able to find a monograph on a canadian web site. Since it is NOT an FDA approved drug, it can legally be imported because of the *compassionate use* legislation. FDA approved drugs are not legally importable yet.
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> > > The info about Klonopin came from an excellent website called Immune Support that has many different boards: Depression, Chronic Fatigue, Arthritis, Lupus. It has an article in their "Library" entitled Dr Paul Cheney discusses the benefits of Klonopin. It is an EXCELLENT site; well-monitored just like Psycho Babble.
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> Thanks. I'll check it out. I'm ready to ask my doc to prescribe Klonopin + Adderall (or Klonopin + Provigil) for my symptoms of fatigue and APD, and I have not yet seen the Klonopin dosing schedule you describe.
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> > > I am SO frustrated becuz I FINALLY find something that works (provigil plus sonata) and of course, since Sonata has such a short half life I had to take 3-4 pills a day to feel well. (not high or drunk: just normal!)
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> Sonata during the day? you say?
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> > > My pdoc is great but is afraid the DEA will come take her away id she keeps giving me scripts for Sonata.
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> After seven wonderful years together, my doc says that he is willing to prescribe virtually anything I ask for as long as there is the tiniest rationale for it. He has very little history prescribing stimulants though. Which makes me wonder what are a doctors legal issues in prescribing stimulants all of a sudden, and possibly at a somewhat higher dose than the PDR recommends. Is someone really watching him? How close?
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> > > She offered me Ambien last week but it didn't seem to work as well as the sonata; as far as lifting my mood. Plus, I had bad headaches from it. SO, that is why I am trying to research Klonopin. I hate to ask for yet another drug that may do little or nothing. I take Xanax but do not notice any antidepressant effects. In fact, I only need it to counteract the Provigil "meltdown".
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> What is the Provigil "meltdown?"
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> > > Any thoughts on how to find a drug that works on the same Gaba or part of the brain as Sonata?
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> Ambien, Sonata, and Imovane all work on the same GABA receptor subtype, but as to which part of the brain, hard to know.
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> --Jay
>
Thanks much for responding to my post. I appreciate the info you provided. When I was first given Provigil becuz I was so fatigued that I could not get out of bed, it took me a while to figure out that the sudden drop in mood about 5-6 hours after taking the Provigil was FROM the Provigil. (Drop after peak plasma levels, I theorize) I would cry for no reason; overreact to things that never bothered me before; also had these feelings if I took Provigil too late in the day and woke up in the middle of the night with thoughts of total doom and gloom. I noticed when I took the Sonata in the evening that I REALLY did a complete turn around. Like I would think, who was THAT person a few hours ago? Also, stupid songs would continue and contine to play in my mind. One day, I did not take the Provigil and I literally laid on the couch and just rocked and felt like I could not shake the "down" feeling. I never had a racing heart or sweats though. So I didn't think it was anxiety. Eventually, my pdoc gave me Xanax which helped prevent this from happening. But it doesn't give me the uplifting mood like Sonata. SO, after finding out that Klonopin can be given during the day, I thought there might be a connection. IMPORTANT TO NOTE: there is no doubt in my mind that I would have fallen asleep during the day IF I was taking the Sonata alone and NOT in CONJUNCTION with the PROVIGIL.... I am such a calm person that it kills me to take the Provigil (also tried Ritalin and Adderall for a few days) and feel jumpy and shakey.. Interesting about the med from Canada. I belong to a natural thyroid group and someone just posted about their Armour thyroid prescription ordered from online from a Mexican (?) pharmacy. The package was conviscated by the Customs/FDA. She got a letter that said the drug she ordered was available in the USA and there was no need to buy it outside the country. (Problem is, many drs do not believe in natural Armour thyroid, only Synthetic Synthroid which is not the same thing)..Sorry so long--but how ironic how? BTW my pdoc is super! She whips out the PDR when she is unsure about something; even knows if a higher dose pill is cheaper ("just cut it in half") She did tell me once that some drs have gotten sued becuz the drugs they have prescribed have made addicts out of the patients. I don't mean to insult your intelligence but, did you know that Provigil is not the same class of stimulant as Adderall, Dexedrine, or even Ritalin? That is probably why she gave it to me first. I ALWAYS had trouble with SSRIs causing drowsiness and provigil was used to help counteract this. I better stop for now. Hope I answered your questions...You DID have a question..didn't you? I get very carried away when I start to write..
poster:florence
thread:345256
URL: http://www.dr-bob.org/babble/20040510/msgs/345540.html