Posted by zeugma on May 25, 2004, at 18:46:57
In reply to Re: wash-out before maoi » zeugma, posted by King Vultan on May 25, 2004, at 14:21:31
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> > What does your book tell you about the receptor blocking affinities of clomipramine? Probably both 5HT-1A and 5HT 2A blockade is therapeutic for me. The great experiment will be to see what 5HT reuptake inhibition does for me, since I have never taken one long enough to determine the nature of its effects. My hope is that the other actions of clomipramine will make the SRI effects tolerable.
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> Clomipramine
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> NE reuptake............+++
> 5HT reuptake........+++++
> DA reuptake..............+
> Blockade 5HT1.........+
> Blockade 5HT2.......+++
> Blockade ACh.........+++
> Blockade H1...........+++
> Blockade alpha-1....+++
> Blockade alpha-2......+
> Blockade D2............++
>
> where each + represents a difference of one order of magnitude for Ki, ranging from
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> +++++ represents Ki = 0.1-1.0
> + represents Ki = 1000-10000
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>
> Todd
>Thank you for the info. My pdoc said I could swap nortrip for clomip one-to-one. That was a lot of my reason for wanting to try clomip instead of my lex samples in the first place. The TCA depressant/antidepressant combo (monoamine reuptake blockade vs. H1/5HT blockade) is why I think I responded to nortrip, and is the clue I will follow as i experiment with clomipramine.
By the way, do you think clomipramine + stimulant comes as close to an MAOI as is possible without actually taking one? My thought is that it might COMBINE the attributes of Parnate and Nardil. (In this comparison I would also include the GABAergic effects of the clonazepam I also take.)
poster:zeugma
thread:348690
URL: http://www.dr-bob.org/babble/20040521/msgs/350566.html