Posted by King Vultan on June 2, 2004, at 17:11:54
In reply to Re: tolerance to desipramine impotence and tachycardia, posted by stjames on June 2, 2004, at 16:40:10
> > Trazodone might fix the erection problems: http://www.bjui.org/85/7/article/bju601.asp but it would make your blood pressure & tachycardia worse.
> >
> > Cheers,
> > Panda.
>
> Whoa...very wrong here. Trazo is well known for
> Priapism, a sustained erection that causes damage
> and often requires surgical intervention. Tends to leave one unable to get an erection.
>
> Abber JC, Lue TF, Luo J–A, Juenemann K–P, Tanagho EA. Priapism induced by chlorpromazine and trazodone: mechanism of action. J Urol 1987; 137: 1039–42
>
>I think what Panda is implying is that trazodone has a pro-erectile effect, that is, it tends to encourage erections. I'm assuming this is because of its alpha-1 and alpha-2 adrenergic blockades. Yes, priapism has been noted as occurring with trazodone, but this is relatively rare (1 out of 6000-7000 chance). My own observation taking various drugs with alpha-1 blockades is that they do tend to promote erections. The BPH drug Flomax, which is an alpha-1 blocker selective for the 1a receptors in the prostate, also has a chance of causing priapism, but it is only about 1 in 50,000.
Todd
poster:King Vultan
thread:352932
URL: http://www.dr-bob.org/babble/20040602/msgs/353109.html