Posted by Sad Panda on June 3, 2004, at 3:11:08
In reply to cyproheptadine sucks, posted by Questionmark on June 3, 2004, at 1:55:11
> Okay, i have a prescription for 4mg cyproheptadine (Periactin) tablets to help combat my atrocious anorgasmia from Nardil (60mg/day). The other night i took a full 4mg tablet for only the second time and am now pretty convinced that i hate it. Not only did it not help with the anorgasmia, but during the process of doing what i was using it for, i was so stINKing drowsy that any caresses and what not just kept putting me into little microsleeps! i was so dang tired that i couldn't even concentrate on what i was doing or even stay fully awake! And on top of all THAT, Mr. Softy Jenkins complETEly "fell asleep"!! (And i do not normally suffer from ED so this was especially surprising and frusterating.) All of this also occurred the only other time i took a full 4mg of cyproheptadine (which really isn't even that much either, i believe).
> And then today-- as with the 1st time-- i have been HORRIbly tired and lethargic all freaking day. It feels remarkably similar to antihistamine "hangovers" from other H1 antagonists. This is not surprising since it also has H1-blocking properties, but i read somewhere that it had a half-life of 4 hours so i didn't think i would have to deal with the next-day fatigue and stupifaction like i do with diphenhydramine and, ugh, Remeron. But no, i have slept almost this entire day. FORTunately i didn't have anything important to do today. Also, fortunately, i didn't really notice any antiserotonergic effects, and i tried to be observant about that (although i wANTed the antiserotonergic property of an ease in ability to orgasm). But the antihistamine effects were enough to make me ticked off and hate the stupid drug.
> Thus, cyproheptadine, like Remeron, was a bust. And i would advise anyone interested in it who is sensitive to antihistamine effects to either be very judicious or to use another route.
> Why can't they make a 5-HT2 (is it 5-HT2A or 5-HT2C, or both?) antagonist that's not also a potent antihistamine?!
> Next up, amantadine. (No more H1 blockers for awhile).
>
> Oh, P.S., if anyone has any idea, what do you think the reason would be for the ED that i experienced with cyproheptadine? Is it strongly anticholinergic?
>
>Your ED problem was probably due to a lack of interest since you were falling asleep.
Not surprising that Periactin but you to sleep, it is mostly used as an antihistamine or secondly for migranie prevention. Remeron works for me, but you have to take it daily so you can build tolerence to the sedating effect of H1 blockade. I take mine at midnight, but I can still stay up untill sunrise if I want as I have developed 100% immunity from it.
Cheers,
Panda.
poster:Sad Panda
thread:353270
URL: http://www.dr-bob.org/babble/20040602/msgs/353276.html