Posted by chemist on June 12, 2004, at 16:49:19
In reply to Don't you know............?, posted by Racer on June 12, 2004, at 12:09:30
ni racer, thanks for the kind words....i know the other posters know more about this stuff than i do, and my response is gleaned from my cursory literature/refs, but: effexor. strong S/NE RI, weak on the dopamine. likely to cause weight loss. give a shout to panda, ace, jbl121, SLS, or vultan: they're way more up on this than i am. the other one you might consider is wellbutrin, but from what understand, doesn't pack the S/NE punch that effexor does. now, about your bonus question: i'd like to say leptin, but see Science 304 (5667):108-110 (2004). if you want the PDF (or anyone else), let me know. all the best in your quest, chemist
> It's good to see you back, and to make sure this fits on the Meds board, can you answer a question about meds for me?
>
> Here's what I think I've gathered regarding drugs that affect the norepinephrine systems: they do tend to cause the most weight gain, and that's a function of their effect on norepinephrine. Unfortunately, they're also the drugs that tend to do best for me, with a little bit of dopamine action a real boon for augmenting that response. Kinda puts me into a real bind, since the weight gain is a big part of the reason that I keep stopping the meds after a couple of years, leading to another major depressive episode. That's the background.
>
> What can you suggest regarding a drug that hits NE pretty strongly, gives DA a kick on the shins as it goes by, and has the most benign side effect profile regarding those nasties like weight gain, constipation, sedation?
>
> And here's the kicker question. Get this right and I'll give you a lollipop (or a Guiness Extra Stout next time you're in CA).
>
> Are there any biochemical mechanisms to reduce the weight gain/constipation/etc WITHOUT reducing the effectiveness of the anti-depressant resonse?
>
> (There, now this is a med related thread. What a relief!)
poster:chemist
thread:355893
URL: http://www.dr-bob.org/babble/20040608/msgs/356115.html