Re: TCAs and SSRIs - A good mix?

Posted by King Vultan on July 29, 2004, at 12:19:20

In reply to TCAs and SSRIs - A good mix?, posted by RetiredYoung on July 29, 2004, at 11:20:39

> I've read on numerous occasions that certain tricyclic ADs should not be mixed with certain SSRIs. However, some mixes actually seem to be appropriate.
>
> Anyone have a source or more info as to which TCA/SSRI combos are effective and safe, and why others are not?? Txs.
The caution has to do with enzyme interactions between certain SSRIs and tricyclics that can boost blood plasma levels of the tricyclic to dangerous levels (all tricyclics are lethal in overdose). The big one to be concerned about is the extremely powerful 2D6 enzyme inhibition of both Prozac and Paxil. These two drugs should not be combined with tricyclic antidepressants unless you really know what you're doing. This would include starting out at a low level of the tricyclic and then monitoring blood plasma levels of the tricyclic to make sure that the dosage is at a safe level.
Todd

Thread

TCAs and SSRIs - A good mix? RetiredYoung 7/29/04
Re: TCAs and SSRIs - A good mix? linkadge 7/29/04
Re: TCAs and SSRIs - A good mix? » linkadge Larry Hoover 7/29/04
Re: TCAs and SSRIs - A good mix? King Vultan 7/29/04
Re: TCAs and SSRIs - A good mix? RetiredYoung 7/29/04
Re: TCAs and SSRIs - A good mix? » RetiredYoung King Vultan 7/29/04
Re: TCAs and SSRIs - A good mix? » King Vultan Larry Hoover 7/29/04
Re: TCAs and SSRIs - A good mix? Sad Panda 7/30/04

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