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Re: Any Lofepramine experiences? Any good for anxiety? » TheOutsider

Posted by King Vultan on August 3, 2004, at 8:03:28

In reply to Any Lofepramine experiences? Any good for anxiety?, posted by TheOutsider on August 3, 2004, at 6:04:57

> I am possibly thinking about trying lofepramine, but can find very little information about its effects.
> Any one who's taken it, I'd love to hear what its like!


Lofepramine is what is called a prodrug, that is, a drug precursor. In this case, the drug that the body metabolizes it into is desipramine, which is a selective norepinephrine reuptake inhibitor with relatively low side effects for a tricyclic. I've taken desipramine myself and rate it as one of the two best ADs I've taken, but IMO, it is not a great choice for someone who already has anxiety problems. My anxiety levels nowadays are only average, and I have actually never even taken a benzo for anxiety (there were times in the past when I could have used one, though), but I found that desipramine significantly boosted my anxiety when I first started taking it. That be said, I did get used to it after a while, but it took a month or more. I find desipramine to be rather activating and uplifting, as well as being helpful on a cognitive/concentration level.

Todd


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